DNA microarrays and development
نویسندگان
چکیده
منابع مشابه
DNA microarrays and development.
Gene expression is a central concept in molecular biology: its control, frequently exquisite in terms of cell specificity and timing, forms part of our explanation of most biological processes. The importance of the control of gene expression for developmental biologists is made obvious by just considering the nature of their discipline. Development is the term we use to describe the coordinati...
متن کاملDevelopment and validation of corynebacterium DNA microarrays.
We have developed DNA microarray techniques for studying Corynebacterium glutamicum. A set of 52 C. glutamicum genes encoding enzymes from primary metabolism was amplified by PCR and printed in triplicate onto glass slides. Total RNA was extracted from cells harvested during the exponential-growth and lysine production phases of a C. glutamicum fermentation. Fluorescently labeled cDNAs were pre...
متن کاملHistorical Concept and Development of Dna Microarrays
DNA microarrays were first described in 1995 for simultaneous analysis of a large-scale gene expression patterns. Since then, they have moved to center stage in many areas of biological research and now assuming an increasingly important role in diagnostics, genomics, pharmacology, cancer and other biomedical research, among others. In this article, we discuss the scientific background and prin...
متن کاملDNA microarrays and pharmacogenomics.
The DNA microarrays have proven to be a state of the art technique for high throughput comprehensive analysis of thousand of genes in parallel. The application of a DNA microarray to compare normal and pathological cells, tissues or organs may allow, along with classical positional cloning techniques, to speed up the discovery of genes and gene pathways implicated in several diseases. This in t...
متن کاملDNA biosensors and microarrays.
Laboratoire de Génie Enzymatique et Biomoléculaire, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, 43 Boulevard du 11 Novembre 1918, Villeurbanne F-69622, France, UMR5246, Centre National de La Recherche Scientifque, Villeurbanne F-69622, France, Université de Lyon, Lyon F-69622, France, Université Lyon 1, Lyon F-69622, France, Institut National des Sciences Appliquées de Ly...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2003
ISSN: 1460-2083
DOI: 10.1093/hmg/ddg053